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Slander (6)

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6

7 10 12

'slander' is the definition.
(synonyms)

This is all the clue.

(Other definitions for defame that I've seen before include "Attack good reputation, speak ill of" , "Attack someone's good name" , "Injure the reputation of" , "Asperse" , "libel" .)

I've seen this clue in The Mirror and the Evening Standard.
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