Sponge from a sucker being set up (5)
I believe the answer is:
loofa
'sponge' is the definition.
(I've seen this before)
'a sucker being set up' is the wordplay.
'sucker' becomes 'fool' ('fool' can be a synonym of 'sucker').
'being set up' says the letters should be written in reverse.
'a'+'fool'='afool'
'afool' written backwards gives 'LOOFA'.
'from' acts as a link.
(Other definitions for loofa that I've seen before include "bathing accessory" , "Bath sponge" , "Gourd used as a sponge" , "American scrubber" , "cleaner" .)