Sponge from a sucker being set up (5)
I believe the answer is:
Here is my best explanation:
'sponge' is the definition.
Although both the answer and definition are singular nouns, I cannot see how one could define the other.
'a sucker being set up' is the subsidiary indication.
'sucker' becomes 'fool' ('fool' can be a synonym of 'sucker').
'being set up' is a reversal indicator.
'afool' back-to-front is 'loofa'.
'from' is the link.
(Other definitions for loofa that I've seen before include "One in bath", "washer", "Gourd used as a sponge", "Bath sponge", "bathing accessory", "back-scratcher?", "Firm sponge", "American scrubber", "Fruit used for a sponge" and "Sponge".)