Suffer at home with effective treatment in short supply (5)
I believe the answer is:
incur
'suffer at home' is the definition.
'incur' can be an answer for 'suffer' (I've seen this before). I'm not sure about the 'at home' bit.
'effective treatment in short supply' is the wordplay.
'effective' becomes 'in' (I can't justify this - if you can you should give a lot more credence to this answer).
'treatment' becomes 'cure' (cure is a kind of treatment).
'in short supply' means to remove the last letter.
'cure' with its final letter removed is 'cur'.
'in'+'cur'='INCUR'
'with' is the link.
Can you help me to learn more?
(Other definitions for incur that I've seen before include "Bring upon oneself - be liable for" , "Become liable or subject to" , "Become subject to (something unpleasant)" , "Attract" , "Fall into - invite" .)