Tailor sets rules -- no uniform is itchy (8)
I believe the answer is:
restless
'itchy' is the definition.
('restless' can be a synonym of 'itchy')
'tailor sets rules no uniform' is the wordplay.
'tailor' indicates an anagram (I've seen this in other clues).
'no' is a deletion indicator.
'uniform' becomes 'u' (phonetic alphabet: alpha, bravo, charlie etc.).
'sets'+'rules'='setsrules'
'setsrules' with 'u' taken out is 'setsrles'.
'setsrles' with letters rearranged gives 'RESTLESS'.
'is' is the link.
(Other definitions for restless that I've seen before include "Fidgety, uneasy" , "Unable to relax or be still" , "Unsettled, fidgety" , "Wakeful" , "Unable to sit still" .)