Takes a very long time for the Wise Guys to head off (4)

I believe the answer is:

ages

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'takes' is the definition.
The answer and definition can be both related to bodily activities as well as being verbs in their -s form.
Perhaps you can see a link between them that I don't see?

I don't understand the rest of the clue.

Can you help me to learn more?

(Other definitions for ages that I've seen before include "(What seems) a very long time" , "A long time (colloq.)" , "Times" , "Aeons" , "Historic periods or prolonged time" .)

I've seen this clue in the Irish Times and the Irish Times (Crosaire).

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