They have depressing experiences, topless (6)
I believe the answer is:
'they have' is the definition.
(I've seen this before)
'depressing experiences topless' is the wordplay.
'depressing experiences' becomes 'downers' (I've seen this in another clue).
'topless' means to remove the first letter.
'downers' with its first letter removed is 'OWNERS'.
(Other definitions for owners that I've seen before include "Worsen for possessors" , "Holders, possessors" , "Legal possessors" , "Proprietors" , "Those in lawful possession, as of house" .)