To begin with, some townspeople really annoy newcomer (8)
I believe the answer is:
stranger
'newcomer' is the definition.
(I've seen this before)
'to begin with some townspeople really annoy' is the wordplay.
'to begin with' says to take the initial letters.
'annoy' becomes 'anger' (I've seen this before).
The first letters of 'some townspeople really' is 'str'.
'str'+'anger'='STRANGER'
(Other definitions for stranger that I've seen before include "More odd or weird" , "Person in place or company to which he does not belong" , "Less familiar" , "Regrants oddly to person unknown" , "visitor" .)