Tongue-tied single, taciturn with ale drunk (12)
I believe the answer is:
Here is my best explanation:
'tongue-tied' is the definition.
('inarticulate' can be similar in meaning to 'tongue-tied')
'single taciturn with ale drunk' is the subsidiary indication.
'single' becomes 'i' (one).
'with' means one lot of letters go next to another.
'drunk' is an anagram indicator.
'taciturn' put after 'ale' is 'aletaciturn'.
'aletaciturn' with letters rearranged gives 'narticulate'.
(Other definitions for inarticulate that I've seen before include "Unable to speak clearly", "Incomprehensible", "Not able to speak coherently", "Unintelligible", "I taunt a relic (anag.)", "Unable to express oneself clearly", "Tongue-tied", "Not clearly expressed" and "Lacking fluency".)