Well-informed American went over instruction to read more (2,2,5)
I believe the answer is:
up to speed
'well-informed' is the definition.
(I've seen this in another clue)
'american went over instruction to read more' is the wordplay.
I cannot really understand how this works, but
'went' could be 'peed' (both can mean urinated) and 'peed' is located in the answer.
'over' could be 'up' (e.g. if your time is up it is over) and 'up' is present in the answer.
'to' is found in the answer.
A single letter 's' remains which might be clued in a way I don't see.
This explanation may well be incorrect...
Can you help me to learn more?
(Other definitions for up to speed that I've seen before include "fully informed" , "at full pace" , "In the know" .)