Creepy-crawly noticed her, we hear (6)
I believe the answer is:
spider
'creepy-crawly' is the definition.
(spider is a kind of invertebrate)
'noticed her we hear' is the wordplay.
I cannot really understand how this works, but
'her' could be 'de' and 'de' is found within the answer.
This may be the basis of the clue (or it may be nonsense).
Can you help me to learn more?
(Other definitions for spider that I've seen before include "Tarantula, say?" , "Snooker-cue rest" , "Predatory arachnid" , "Black widow or redback?" , "Harvester" .)