Despair's ending: two biblical characters help (7)
I believe the answer is:
relieve
'help' is the definition.
(I've seen this before)
I can't explain the remainder of the clue.
Can you help me to learn more?
(Other definitions for relieve that I've seen before include "Assuage, ease" , "Make less tedious, bring aid to (besieged place)" , "Palliate" , "Soothe" , "cure" .)