Note setter of renown (4)
I believe the answer is:
fame
'renown' is the definition.
(synonyms)
'note setter' is the wordplay.
'note' becomes 'fa' (musical note).
'setter' becomes 'me' (the setter of the clue).
'fa'+'me'='FAME'
'of' acts as a link.
(Other definitions for fame that I've seen before include "Prominence" , "''... is the spur that the clear spirit doth raise (Lycidas, John Milton)" , "Note" , "Celebrity; stage musical" , "Favourable public reputation" .)