Try writing about industrial problem (4)
I believe the answer is:
smog
'industrial problem' is the definition.
(I've seen this in another clue)
'try writing about' is the wordplay.
'try' becomes 'go' (both can mean an attempt).
'writing' becomes 'MS' (abbreviation for manuscript).
'about' says the letters should be written in reverse.
'go'+'ms'='goms'
'goms' in reverse letter order is 'SMOG'.
(Other definitions for smog that I've seen before include "Thick polluted mist" , "Pea-souper" , "Pollutant haze" , "Pollutant fog" , "Dirty mixture of smoke and fog" .)