Wild female, real crazy (5)
I believe the answer is:
feral
'wild' is the definition.
(similar in meaning)
'female real crazy' is the wordplay.
'female' becomes 'f' (common abbreviation).
'crazy' indicates an anagram.
'real' anagrammed gives 'eral'.
'f'+'eral'='FERAL'
(Other definitions for feral that I've seen before include "Wild but originally domestic" , "Fierce, having reverted to wild state" , "Wild (though once tame)" , "beastly" , "'Savage, wild (5)'" .)