Abandon fool perhaps, losing heart (6)
I believe the answer is:
Here is my best explanation:
'abandon' is the definition.
('desert' can be a synonym of 'abandon')
'fool perhaps losing heart' is the wordplay.
'fool perhaps' becomes 'dessert' (fool is a type of dessert).
'losing heart' means to remove the middle letters.
'dessert' with its centre removed is 'DESERT'.