Affecting the entire body (8)
I believe the answer is:
systemic
'affecting the entire body' is the definition.
(I've seen this in another clue)
This is the entire clue.
(Other definitions for systemic that I've seen before include "City mess (anag)" , "My sect is concerned with affecting the whole body" , "insecticide" , "Relating to the whole organism" , "Affecting a body, institution, etc as a whole" .)