African natives from city in the way of … (5)
I believe the answer is:
nyala
'african natives' is the definition.
(antelopes native to Africa)
'city in the way of' is the wordplay.
'city' becomes 'ny' (short for New York).
'in the way of' becomes 'a la' ('a la', French phrase meaning 'in the style of').
'ny'+'ala'='NYALA'
'from' is the link.
(Other definitions for nyala that I've seen before include "Spiral-horned antelope" , "wild animal" , "Ruminant" , "South African resident" , "South African native" .)