After loudly interrupting, are quiet again (6)
I believe the answer is:
afresh
'again' is the definition.
(synonyms)
'after loudly interrupting are quiet' is the wordplay.
'after' says to put letters next to each other.
'loudly' becomes 'f' (short for forte - 'loud' in music).
'interrupting' is an insertion indicator.
'quiet' becomes 'sh' (both can be said to tell someone to be quiet).
'f' going into 'are' is 'afre'.
'afre' put next to 'sh' is 'AFRESH'.
(Other definitions for afresh that I've seen before include "Academy award" , "Anew, from the beginning" , "Newly" , "In a different way" , "In a new way" .)