Alienated (11)
'alienated' is the definition.
(I know that alienated can be written as estranged)
This is the entire clue.
(Other definitions for estranged that I've seen before include "Alienated, disaffected" , "no longer friendly" , "Sad regent (anag) - disaffected" , "Having become unfriendly or alienated" , "Cut off" .)
'alienated' is the definition.
('disaffect' can be a synonym of 'alienate')
This is all the clue.
(Other definitions for disaffected that I've seen before include "Out of sympathy with those in power" , "Rebellious" , "No longer supporting those in power" , "Alienated from authority" , "No longer willing to support those in authority" .)