American tangles with favourite — who’s defeated in this? (5)
I believe the answer is:
upset
'defeated in this?' is the definition.
'upset' can be an answer for 'defeated' (I've seen this in another clue). I'm not certain of the 'in this?' bit.
I don't understand how the remainder of the clue works.
Can you help me to learn more?
(Other definitions for upset that I've seen before include "Overturn or discompose" , "Upheaval" , "Discomfit" , "Make unhappy; disrupt" , "Disturb - spoil" .)