Anne is unfortunately quite mad (6)
I believe the answer is:
insane
'quite mad' is the definition.
(I've seen this before)
'anne is unfortunately' is the wordplay.
'unfortunately' indicates an anagram (a bad or unfortunate spelling).
'anne'+'is'='anneis'
'anneis' is an anagram of 'INSANE'.
(Other definitions for insane that I've seen before include "reckless" , "Anne is (anag) - crazy" , "Quite mad" , "Mentally unhinged" , "Irresponsible" .)