Annoy when spilling kir (3)
I believe the answer is:
irk
'annoy' is the definition.
(I've seen this before)
'spilling kir' is the wordplay.
'spilling' is an anagram indicator.
'kir' is an anagram of 'IRK'.
'when' acts as a link.
(Other definitions for irk that I've seen before include "Wind up" , "Irritate, annoy" , "English river" , "upset" , "Gall" .)