Artist’s workplace and breeding establishment originally in Oxford (6)
I believe the answer is:
studio
'artist's workplace' is the definition.
(I've seen this in another clue)
'breeding establishment originally in oxford' is the wordplay.
'breeding establishment' becomes 'stud' (I've seen this before).
'originally' says to take the initial letters.
The initial letters of 'in oxford' is 'io'.
'stud'+'io'='STUDIO'
'and' is the link.
(Other definitions for studio that I've seen before include "An artist may work in this room" , "Elstree area" , "Workroom for 27 down" , "Apartment with one main room" , "Where one might find artists" .)