Averse to making a profit on the way (7)
I believe the answer is:
against
'averse to' is the definition.
(to be averse to something is to be against it)
'a profit on the way' is the wordplay.
'profit' becomes 'gain' (synonyms).
'on' says to put letters next to each other.
'the way' becomes 'st' (abbreviation for street).
'a'+'gain'+'st'='AGAINST'
'making' acts as a link.
(Other definitions for against that I've seen before include "Opposite to" , "Con" , "Opposing" , "Anti, touching" , "Placed in direct contact with" .)