Can't stand trial following extremes of disease (6)
I believe the answer is:
detest
'can't stand' is the definition.
(I've seen this in another clue)
'trial following extremes of disease' is the wordplay.
'trial' becomes 'test' (synonyms).
'following' means one lot of letters go next to another.
'extremes of' says to hollow out the word (remove centre letters).
'disease' with its middle removed is 'de'.
'test' after 'de' is 'DETEST'.
(Other definitions for detest that I've seen before include "Dislike intensely, loathe" , "can't stand" , "Greatly hate" , "Dislike intensely, think badly of" , "Hate a lot" .)