Changing one's residence may be poignant (6)
I believe the answer is:
moving
This clue might be a double definition.
'changing one's residence' is the first definition.
'moving' can be an answer for 'changing' (moving is a kind of changing). I'm unsure of the 'one's residence' bit.
'poignant' is the second definition.
(similar in meaning)
'may be' acts as a link.
Can you help me to learn more?
(Other definitions for moving that I've seen before include "Arousing strong emotion" , "Arousing feelings of pity etc" , "Emotional" , "Going to other places" , "Changing house, say" .)