Choke with ale going the wrong way down this? (8)
I believe the answer is:
cakehole
'down this?' is the definition.
I know nothing about this answer so I cannot judge whether this works.
'choke with ale going the wrong way' is the wordplay.
'with' means one lot of letters go next to another.
'going the wrong way' indicates an anagram.
'choke'+'ale'='chokeale'
'chokeale' with letters rearranged gives 'CAKEHOLE'.
(Other definitions for cakehole that I've seen before include "What a doughnut might have" , "Gob (slang)" , "Mouth (slang)" , "Chops" , "Echo leak (anag) - gob" .)