Condemn to mood changes (4)
I believe the answer is:
doom
'condemn' is the definition.
(I know that condemn can be written as doom)
'mood changes' is the wordplay.
'changes' indicates anagramming the letters.
'mood' with letters rearranged gives 'DOOM'.
'to' acts as a link.
(Other definitions for doom that I've seen before include "Condemn (to certain death?)" , "Fate, destiny" , "A bad lot" , "Unavoidable ill-fortune" , "Terrible fate; death" .)