Cotton fabric skin for instance has to perish (8)
I believe the answer is:
organdie
'cotton fabric skin' is the definition.
I can't judge whether this definition defines the answer.
'for instance has to perish' is the wordplay.
'for instance' becomes 'organ' (I can't justify this - if you can you should give a lot more credence to this answer).
'has' means one lot of letters go next to another.
'to perish' becomes 'die' ('die' can be a synonym of 'perish').
'organ'+'die'='ORGANDIE'
Can you help me to learn more?
(Other definitions for organdie that I've seen before include "Fine material" , "Orange I'd changed for fine muslin" , "Fine stiffened translucent fabric" , "I raged on about the fabric" , "I groaned about translucent fabric" .)