Create a fuss as Adam and Eve had to do (5,4)
I believe the answer is:
raise cain
'adam and eve had to do' is the definition.
I don't know anything about this answer so I cannot judge whether this works.
'create a fuss' is the wordplay.
'create' becomes 'raise' (raising is a kind of creating).
'a fuss' becomes 'cain' (I can't justify this - if you can you should give a lot more credence to this answer).
'raise'+'cain'='RAISE CAIN'
'as' acts as a link.
Can you help me to learn more?
(Other definitions for raise cain that I've seen before include "Cause a noisy disturbance" , "Make an angry fuss" , "Make a lot of noise (in anger)" , "Make an uproar - lift Abel's brother" , "Cause a commotion" .)