Dale and Virginia shout up (6)
I believe the answer is:
valley
'dale' is the definition.
(I know that dale can be written as Valley)
'virginia shout up' is the wordplay.
'virginia' becomes 'va' (US state abbreviation).
'shout' becomes 'yell' (yelling is a kind of shouting).
'up' shows that the letters should be reversed in order (in down clue: letters go upwards).
'yell' in reverse letter order is 'lley'.
'va'+'lley'='VALLEY'
'and' is the link.
(Other definitions for valley that I've seen before include "Depression between ranges of hills" , "Hollow between hills" , "Dale, dene or glen" , "one running between hills" , "Flat area among hills" .)