Deal with story about Calvin Klein initially (6)
I believe the answer is:
tackle
'deal with' is the definition.
(I've seen this before)
'story about calvin klein initially' is the wordplay.
'story' becomes 'tale' (synonyms).
'about' is an insertion indicator.
'initially' says to take the initial letters.
The initial letters of 'calvin klein' is 'ck'.
'tale' going around 'ck' is 'TACKLE'.
(Other definitions for tackle that I've seen before include "block" , "Compete for ball" , "things" , "Go for the person with the ball" , "Take on as in rugby" .)