Despair (4,4)
<span class="explanation-format__ClueExplanation">'<span class="explanation-format__original">despair</span>' is the definition.<br/ ><span class="explanation-format__explanation">(I know that despond is a more specific form of the action despair)</span><br/ ><br/ >This is all the clue.<br/ ></span>
(Other definitions for despond that I've seen before include "Its Slough, Bunyan" , "Become disheartened" .)
<span class="explanation-format__ClueExplanation">'<span class="explanation-format__original">despair</span>' is the definition.<br/ ><span class="explanation-format__explanation">(synonyms)</span><br/ ><br/ >This is the entire clue.<br/ ></span>
(Other definitions for lose hope that I've seen before include "Despair" , "Become pessimistic" .)