Desperate man has twisted his tongue (6)
I believe the answer is:
danish
'tongue' is the definition.
(Danish is an example)
'desperate man has twisted his' is the wordplay.
'desperate man' becomes 'Dan' (as in Desperate Dan comics).
'has' is a charade indicator (letters next to each other).
'twisted' is an anagram indicator.
'his' is an anagram of 'ish'.
'dan'+'ish'='DANISH'
(Other definitions for danish that I've seen before include "Copenhagen this capital" , "Flat cake - and party's his! (anag)" , "Hamlet was and bacon may be" , "Language of Denmark" , "Relating to Denmark" .)