Detrimental at home getting one claim settled (8)
I believe the answer is:
inimical
'detrimental' is the definition.
(thesaurus)
'home getting one claim settled' is the wordplay.
'home' becomes 'in' ('he's home' can mean 'he's in').
'getting' is an insertion indicator.
'one' becomes 'i' (Roman numeral).
'settled' indicates anagramming the letters.
'claim' is an anagram of 'mical'.
'i' inserted into 'mical' is 'imical'.
'in'+'imical'='INIMICAL'
'at' acts as a link.
(Other definitions for inimical that I've seen before include "In claim I am strangely hostile" , "Hostile or harmful" , "Hostile, unfavourable" , "Injurious - hostile" , "Pernicious" .)