Devil leaving Black Death region in London (4,3)
I believe the answer is:
east end
'region in london' is the definition.
(East End of London)
'devil leaving black death' is the wordplay.
I cannot quite understand how this works, but
'death' could be 'end' (synonyms) and 'end' is located in the answer.
The remaining letters 'east' is a valid word which might be clued in a way I don't understand.
This may be the basis of clue (or it may be nonsense).
Can you help me to learn more?
(Other definitions for east end that I've seen before include "Area of London, featured in a TV soap opera" , "7 Down in London" , "Send tea (anag.)" , "Cockneyland" , "Bow" .)