Dickensian villain, female, with a drink (5)
I believe the answer is:
fagin
'dickensian villain' is the definition.
(character in Charles Dickens' Oliver Twist)
'female with a drink' is the wordplay.
'female' becomes 'f' (abbreviation).
'with' is a charade indicator (letters next to each other).
'drink' becomes 'gin' (gin is an alcoholic drink).
'f'+'a'+'gin'='FAGIN'
(Other definitions for fagin that I've seen before include "Thief" , "Dickens villain" , "Gang leader (Oliver Twist)" , "he hanged" , "Oliver Twist villain" .)