Direction taken by cool detectives coming across ecstasy from Caribbean islands (4,6)
I believe the answer is:
west indies
'caribbean islands' is the definition.
(I've seen this before)
'direction taken by cool detectives coming' is the wordplay.
'direction' becomes 'west' (west is a kind of direction).
'taken by cool detectives coming' becomes 'indies' (I can't explain this - if you can you should believe this answer much more).
'west'+'indies'='WEST INDIES'
'across ecstasy from' is the link.
I am not very happy about this link. Some or all of it may be part of another bit of the clue.
Can you help me to learn more?
(Other definitions for west indies that I've seen before include "Archipelago, largest island is Cuba" , "Caribbean islands" , "Cricket side" , "Cricket team" .)