Father Edward's first in wood once more (6)
I believe the answer is:
afresh
'once more' is the definition.
(I've seen this before)
'father edward's first in wood' is the wordplay.
'father' becomes 'fr' (abbreviation as in a priest's title).
'edward's first' becomes 'e' (1st letter of 'edward').
'in' indicates putting letters inside.
'wood' becomes 'ash' (wood from an ash tree).
'fr'+'e'='fre'
'fre' inserted within 'ash' is 'AFRESH'.
(Other definitions for afresh that I've seen before include "Newly" , "Academy award" , "In a new way" , "Anew, from the beginning" , "In a different way" .)