Fed up with a new editor, the fathead! (5,2)
I believe the answer is:
tired of
'fed up with' is the definition.
(I've seen this in another clue)
'a new editor the fathead' is the wordplay.
'a new' indicates an anagram.
'the fathead' becomes 'f' (head letter of 'fat').
'editor' is an anagram of 'tiredo'.
'tiredo'+'f'='TIRED OF'
(Another definition for tired of that I've seen is " Bored with".)
I've seen this clue in the Evening Standard.
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