Fluffy 'sciences' I cast off, wanting independence (4-11)

I believe the answer is:

self-sufficiency

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'off wanting independence' is the definition.
'self-sufficiency' can be an answer for 'independence' (self-sufficiency is a kind of independence). I am not sure about the 'off wanting' bit.

'fluffy sciences i cast' is the wordplay.
'cast' is an anagram indicator (letters are dispersed or cast around).
'fluffy'+'sciences'+'i'='fluffysciencesi'
'fluffysciencesi' is an anagram of 'SELF-SUFFICIENCY'.

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I've seen this clue in The Everyman puzzle in The Observer.

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