Fly with some characters in jet set, several (6)
I believe the answer is:
tsetse
'fly' is the definition.
(biting fly found in tropical Africa)
'characters in jet set several' is the wordplay.
'characters in' indicates a hidden word.
'TSETSE' is hidden within 'jet set several'.
'with some' acts as a link.
(Other definitions for tsetse that I've seen before include "Disease-carrying fly" , "bloodsucker" , "flies" , "carrier of disease" , "source of sleeping sickness" .)