Following each one, despite everything (5,3)
I believe the answer is:
after all
'one despite everything' is the definition.
(phrase meaning despite everything)
'following each' is the wordplay.
'following' becomes 'after' (I've seen this in other clues).
'each' becomes 'all' (similar in meaning).
'after'+'all'='AFTER ALL'
(Other definitions for after all that I've seen before include "Taking everything into account" , "In spite of everything" , "Nevertheless, when everything has been considered" , "most importantly" , "despite great effort" .)