Forgetfulness of men roaming in large continent (7)
I believe the answer is:
amnesia
'forgetfulness' is the definition.
(I've seen this before)
'men roaming in large continent' is the wordplay.
'roaming' indicates an anagram.
'in' indicates putting letters inside.
'large continent' becomes 'asia' (I've seen this in another clue).
'men' with letters rearranged gives 'mne'.
'mne' going into 'asia' is 'AMNESIA'.
'of' acts as a link.
(Other definitions for amnesia that I've seen before include "Pathological forgetfulness" , "As a mine (anag)" , "Defect in memory" , "illness" , "Medical condition" .)