Game with many skills (5)
I believe the answer is:
darts
'game' is the definition.
(darts is a kind of game)
'with many skills' is the wordplay.
'with' means one lot of letters go next to another.
'many' becomes 'd' (Roman numeral for 500).
'skills' becomes 'arts' (art can mean a skill or talent).
'd' next to 'arts' is 'DARTS'.
(Other definitions for darts that I've seen before include "Game; moves quickly" , "Game with board and missiles" , "Shoots" , "They are thrown at targets in pubs" , "Tears" .)