Gastric woe (5)
I believe the answer is:
ulcer
'gastric woe' is the definition.
(I've seen this in another clue)
This is all the clue.
(Other definitions for ulcer that I've seen before include "Inflammatory and often suppurating lesion on the skin" , "cause of suffering" , "Cruel form of stomach trouble?" , "Stomach complaint" , "Cruel (anag.)" .)