Get infected by wife-to-be hosting midnight card game (8,6)
I believe the answer is:
contract bridge
'card game' is the definition.
(I know that contract bridge is a card game)
'get infected by wife-to-be hosting midnight' is the wordplay.
'get infected by' becomes 'contract'.
'wife' becomes 'bride' (I have seen 'Wife of groom ' mean 'bride' so perhaps 'wife' could also mean 'bride').
'to be hosting' is an insertion indicator.
'midnight' becomes 'g' (the middle letter in 'night').
'bride' placed around 'g' is 'bridge'.
'contract'+'bridge'='CONTRACT BRIDGE'
(Other definitions for contract bridge that I've seen before include "Quartet play this" , "Instruction for nose job, perhaps" , "Card game" , "Wherein four deck hands" , "that requires two pairs of hands" .)