Getting rid of the female guarding one -- worrying about that (10)
I believe the answer is:
cashiering
'getting rid of' is the definition.
(cashiering is a kind of getting rid of)
'the female guarding one worrying about that' is the wordplay.
'the female' becomes 'she' (I've seen this in another clue).
'guarding' indicates putting letters inside.
'one' becomes 'I' (Roman numeral).
'worrying' becomes 'caring'.
'about that' means one lot of letters goes inside another.
'she' placed around 'i' is 'shie'.
'shie' going inside 'caring' is 'CASHIERING'.
(Other definitions for cashiering that I've seen before include "Dismissing a wrongdoer from the armed forces" , "Getting rid of" .)