Get-up-and-go extremely depleted finally? Yes, then doubly so (5)

I believe the answer is:

verve

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'get-up-and-go' is the definition.
(thesaurus)

I can't explain the remainder of the clue.

(Other definitions for verve that I've seen before include "Gusto; energy" , "Animation" , "Root tasting of oysters" , "Vitality" , "Energy and zest" .)

I've seen this clue in The Independent.

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