Glow surrounds religion's first holy place (6)
I believe the answer is:
shrine
'holy place' is the definition.
(holy site dedicated to a particular person)
'glow surrounds religion's first' is the wordplay.
'glow' becomes 'shine' (synonyms).
'surrounds' indicates putting letters inside.
'religion's first' becomes 'r' (1st letter of 'religion').
'shine' placed around 'r' is 'SHRINE'.
(Other definitions for shrine that I've seen before include "Holy place with special associations" , "Tomb or monument of a saint" , "here to pray?" , "Container for sacred relics" , "Place hallowed for special associations" .)